CIS
CIS

Clinical Immunology Society (CIS)

2015 Annual Meeting: Immune Deficiency and Dysregulation North American Conference

2015 Annual Meeting: Immune Deficiency & Dysregulation
North American Conference

April 9-12, 2015
Hilton Americas, Houston, TX
Agenda*

The majority of the sessions will be held on Level Two in the Ballroom of the Americas. Please note that it will abbreviated below as "BOA".

Thursday, April 9    
5:30pm - 6:30pm Welcome Reception
 
BOA A-C
6:30pm - 7:15pm Welcome from CIS President
Donald B. Kohn, MD
University of California, Los Angeles
 
BOA D&E
  .75 AMA PRA Category 1 Credit™
Robert A. Good Lecture
Toward a Genetic Theory of Childhood Infectious Diseases
Jean Laurent Casanova, MD, PhD
The Rockefeller University
 
 
7:30pm - 9:00pm The Scientific Approach to the Patient Experience in Primary Immunodeficiency
Dinner Symposia
1.5 AMA PRA Category 1 Credits™
Moderator:
Troy Torgerson, MD, PhD
University of Washington

Speakers:
Charlotte Cunningham-Rundles, MD, PhD
Mt Sinai Medical Center

Jordan S. Orange, MD, PhD
Baylor College of Medicine

Quality of Life in Patients with Primary Antibody Deficiencies
Isabella Quinti, MD, PhD
Sapienza University of Rome

Supported by an educational grant from Baxter.
BOA A
     
Friday, April 10    
7:00am - 8:00am Breakfast BOA Foyer
7:30am - 8:00am Guided Poster Session
Group 1:
Moderator:
Roshini Sarah Abraham, PhD
Mayo Clinic

STEM CELL TRANSPLANTATION AND LONG-TERM SURVIVAL FOR PRIMARY IMMUNODEFICIENCIES: OUTCOMES AMONG THE DONOR SOURCES AND DIFFERENT DIAGNOSTIC GROUPS
Caridad Martinez, MD
Baylor College of Medicine

RESULTS OF A PHASE III TRIAL IN PATIENTS WITH PIDD USING AN IVIG CONTAINING HIGH TITER NEUTRALIZING ANTIBODY TO RESPIRATORY SYNCYTIAL VIRUS (RSV)
James Mond, MD, PhD
ADMA Biologics

DEEP SEQUENCING OF THE IgH LOCUS IN COMMON VARIABLE IMMUNE DEFICIENCY REVEALS GLOBAL ALTERATIONS IN CENTRAL AND PERIPHERAL B CELL DEVELOPMENT
Noa Simchoni, MD
Icahn School of Medicine at Mt Sinai

RUXOLITINIB EFFECTS ON STAT1 GAIN OF FUNCTION MUTATIONS
Ofer Zimmerman, MD
NIAID

Group 2:
Moderator:
Caroline Kuo, MD
University of California, Los Angeles

TARGETED GENE THERAPY IN THE TREATMENT OF X-LINKED HYPER-IgM SYNDROME
Caroline Kuo, MD
University of California, Los Angeles

HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS CAUSED BY XIAP DEFICIENCY IN A FEMALE PATIENT WITH HETEROZYGOUS BIRC4 MUTATION AND SEVERE X CHROMOSOME SKEWING
Kejian Zhang, MD, MBA
Cincinnati Children's Hospital Medical Center

RECURRENT MYCOBACTERIUM INFECTIONS WITH CD4 LYMPHOPENIA: A MISSED CASE OF NEMO DEFICIENCY
Erinn Samantha Kellner, MD
University of South Florida

EXOME SEQUENCING UNCOVERS A HETEROZYGOUS STAT4 MUTATION IN A FAMILY WITH SUSCEPTIBILITY TO PACAROCCIDIOIDOMYCOSIS
Lena F. Schimke, MD
University of Sao Paulo - Institute of Biomedical Sciences

FUNCTION, PHENOTYPE AND STATS PROTEIN ACTIVATION IN CD56im NK CELLS FROM PATIENTS WITH STAT1 GOF MUTATIONS
Alexander Vargas-Hernandez, PhD
CINVESTAV-IPN
 
BOA A-C
8:00am - 10:00am

 

 
Plenary Session: Cancer Immunotherapy
2 AMA PRA Category 1 Credits™
Moderator:
Steven M. Holland, MD
NIAID, NIH

Speakers:
Immunotherapy with Antigen Specific T Cells
Helen Heslop, MD
Baylor College of Medicine

Natural Killer Cell Effects Against Cancer
Katharine C. Hsu, MD, PhD
Memorial Sloan Kettering Cancer Center

Treating Cancer with PD-1 Blockade
Antoni Ribas, MD
University of California, Los Angeles

Oral Abstracts
ALEMTUZUMAB, FLUDARABINE, AND MELPHALAN REDUCED INTENSITY CONDITIONING REGIMENS ARE SAFE FOR PATIENTS WITH XIAP DEFICIENCY
Rebecca Marsh, MD
Cincinnati Children's Hospital Medical Center
 
BOA D&E
10:00am - 10:30am Morning Break
 
BOA Foyer
10:30am - 11:30am Tales from the Listserv
1 AMA PRA Category 1 Credit™
Moderator:

Mikko Seppänen, MD, PhD
Helsinki University Central Hospital

Mystery Case #1
David Buchbinder, MD, MS
Children's Hospital of Orange County

Mystery Case #2
Megan Cooper, MD, PhD
Washington University

Mystery Case #3
Roshini Sarah Abraham, PhD
Mayo Clinic
Michael B. Jordan, MD
Cincinnati Children's Hospital Medical Center
 
BOA D&E
11:30am - 1:00pm Lunch / Poster Viewing / Exhibit Hall Open
 
BOA A-C
1:00pm - 3:00pm Plenary Session: Auto-Immunity
2 AMA PRA Category 1 Credits™
Moderator:
Elena Hsieh, MD
Stanford University

Speakers:
M. Virginia Pascual, MD
Baylor Institute for Immunology Research

Molecular Mechanism of IFIH1 and Inflammation
Sun Hur, PhD
Harvard Medical School, Boston Children's Hospital

New Mechanisms in Autoinflammation: Interferon-Mediated Autoinflammatory Diseases
Raphaela Goldbach-Mansky, MD
NIAMS, NIH

Oral Abstracts
SEVERE AUTOIMMUNE SYNDROME MEDIATED BY NOVEL MUTATIONS OF ZAP70
Alice Y. Chan, MD, PhD
University of California, San Francisco

MYCHOPHENOLATE MOFETIL AND SIROLIMUS AS SECOND OR FURTHER LINE TREATMENT IN CHILDREN WITH CHRONIC REFRACTORY IDIOPATHIC OR SECONDARY AUTOIMMUNE CYTOPENIAS (AC): A SINGLE CENTER EXPERIENCE
Maurizio Miano, MD
G. Gaslini Research Institute
 
BOA D&E
3:00pm - 3:30pm Afternoon Break
 
BOA Foyer
3:30pm - 5:00pm Concurrent Workshops
1.5 AMA PRA Category 1 Credits™
Session 1 - Telomerase Defects
Moderator:
John Routes, MD
Medical College of Wisconsin

Speakers:
Inflammatory, Senescence and Nutritional Signals Regulate Telomerase in T Cells
Arne Akbar, PhD
University College London

Dyskeratosis Congentia, a Cancer-Prone Syndrome
Blanche P. Alter, MD, MPH
National Cancer Institute
Division of Cancer & Epidemiology & Genetics, Clinical Genetics Branch

Dyskeratosis Congenita, a Disorder of Telomere Maintenance
Alison Bertuch, MD, PhD
Baylor College of Medicine

Session 2 - Cytokines
1.5 AMA PRA Category 1 Credits™
Moderator:
Donald B. Kohn, MD
University of California, Los Angeles

Speakers:
Interleukin 2 Therapy for Wiskott-Aldrich Syndrome
Soma Jyonouchi, MD
Children's Hospital of Philadelphia

Dysregulation of the IL-17 Axis in LAD-I; Mechanisms and Potential for Therapeutic Interventions
Niki Moutsopoulos, DDS, PhD
National Institute of Dental & Craniofacial Research
National Institutes of Health

Variations on Low-Dose IL-2-Based Therapies
Eliane Piaggio, PhD
Inserm

Meeting Room 340













BOA D&E
5:00pm - 5:15pm Late Afternoon Break
 
BOA Foyer
5:15pm - 6:15pm The CIS Fahey/Rose Founders Lecture
1 AMA PRA Category 1 Credit™
Moderator:

Jordan S. Orange, MD, PhD
Baylor College of Medicine

Speaker:
Nature, Nurture, and Infection in the Human Immune System
Mark Davis, PhD
Stanford University
BOA D&E
6:15pm - 8:00pm Improving Health, Empowering Research
USIDNET, the IDF ePHR and PI Connect Reception Symposium

 
BOA A
     
Saturday, April 11    
7:30am - 8:30am Breakfast BOA Foyer
8:00am - 9:30am Concurrent Workshop Sessions
Session 1 - Innate Lymphoid Cells in Immune Homeostasis
1.5 AMA PRA Category 1 Credits™
Moderator:
Elena Hsieh, MD
Stanford University

Speakers:
Innate Immunity and Dementias
Marco Colonna, MD
Washington University School of Medicine

Natural Killer Cell-Mediated Immunological Memory
Silke Paust, PhD
Baylor College of Medicine

Invariant Natural Killer T Cells in Tumor Immunity
Leonid Metelitsa, MD, PhD
Texas Children's Cancer Center

Session 2 - Transplanting the Infected/Inflamed Patient
1.5 AMA PRA Category 1 Credits™
Moderator:

Donald B. Kohn, MD
University of California, Los Angeles

Speakers:
Thrombotic Microangiopathy: A Major Complication of Bone Marrow Transplantation
Lisa Filipovich, MD
Cincinnati Children's Hospital Medical Center

DOCK8 Deficiency: Approach to Translation
Alexandra Freeman, MD
NIAID, NIH

Hematopoietic Stem Cell Transplantation in Patients with Phagocyte Disorders
Tayfun Güngör, MD
University of Zurich

Meeting Room 340














BOA D&E
9:30am - 10:00am CIS Business Meeting & Award Presentation
 
BOA D&E
10:00am - 10:30am Morning Break & Guided Poster Sessions
Group 1
Moderator:
Roshini Sarah Abraham, PhD
Mayo Clinic

NK CELL PHENOTYPIC VARIABILITY IN THE NORMAL ADULT POPULATION
Laura S. Angelo, PhD
Baylor College of Medicine

HUMAN ITCH DEFICIENCY COMPROMISES THE FUNCTION OF FOLLICULAR HELPER T CELLS
Huie Jing, PhD
NIAID, NIH

AUTOSOMAL DOMINANT ECTODERMAL DYSPLASIA AND IMMUNODEFICIENCY IN A MOTHER AND DAUGHTER WITH A SEVERE ECTODERMAL DYSPLASIA AND A MILD IMMUNODEFICIENCY WITH IG DYSREGULATION DUE TO A HETEROZYGOUS NFKBIA MUTATION WITH TERMINATION AT TRP11
Jessie Lee
Royal Prince Alfred Hospital

LONGITUDINAL STUDY OF CVID ILD
Paul J. Maglione, MD, PhD
Mount Sinai School of Medicine

ROLE OF AIRE AND DECTIN RECEPTORS AT THE "FUNGAL SYNAPSE"; A PROPOSED REGULATION OF INNATE IMMUNE RESPONSE TO CANDIDA ALBICANS INFECTION
Jose Antonio Tavares de Albuquerque
Univeristy of Sao Paulo - Institute of Biomedical Sciences

Group 2
Moderator:
Caroline Kuo, MD
University of California, Los Angeles

CLINICAL CHARACTERISTICS AND GENETIC PROFILES OF SEVERE COMBINED IMMUNODEFICIENCY: A SINGLE CENTER EXPERIENCE IN CHINA
Ying-Ying Jin, MD
Shanghai Jiao Tong University School of Medicine

COMPUTATIONAL ANALYSIS IDENTIFIES COMORBIDITY NETWORK CHARACTERIZING INFLAMMATORY BOWEL DISEASE IN COMMON VARIOABLE IMMUNE DEFICIENCY
Mei-Sing Ong, PhD
Boston Children's Hospital

SUBCUTANEOUS IMMUNOGLOBULIN THERAPY IN PATIENTS WITH CHRONIC INFLAMMATORY DEMYELINATING POLYNEUROPATHY
Analía Gisela Seminario, MD
Ricardo Guitiérrez Children's Hospital

STAT 1 GAIN-OF-FUNCTION MUTATION IN PATIENT WITH VISCERAL LEISHMANIASIS AND SECONDARY HEMOPHAGOCYTIC LYMPHOHYSTIOCITOSIS
Paual Teixeira Lyra Marques, MD
Instituto de Medicina Integral Prof. Fernando Figueira

BURKHOLDERIA CEPACIA COMPLEX INFECTION ASSOCIATED WITH DEFECTS IN IL-12 SIGNALING
Christa Zerbe, MD
NIAID, NIH
 
BOA A-C
10:30am - 12:00pm Plenary Session: Vaccines!
1.5 AMA PRA Category 1 Credits™
Moderator:
Sergio Rosenzweig, MD, PhD
NIAID, NIH

Speakers:
NTDs, Blue Marble Health, & the Antipoverty Vaccines
Peter Hotez, MD, PhD
Baylor College of Medicine
(Parasitic Diseases)

cAd3 Ebola Vaccine: Development and Phase I Clinical Trial Results
Julie Ledgerwood, DO
NIAID, NIH

Oral Abstract:
VACCINE-STRAIN VARICELLA-ZOSTER VIRUS-INDUCED ILLNESS IN IMMUNODEFICIENT HOSTS RECEIVING IMMUNOSUPPRESSIVE THERAPY
Cullen M. Dutmer, MD
National Jewish Health, University of Colorado

Panel Discussion
 
BOA D&E
12:00pm - 1:30pm Lunch / Poster Viewing / Exhibit Hall Open
 
BOA A-C
1:30pm - 3:00pm Controversial and Challenges Diagnosing PI In the Office
1.5 AMA PRA Category 1 Credits™
Moderators:

Charlotte Cunningham-Rundles, MD, PhD
Mt Sinai Medical Center
Kathleen Sullivan, MD, PhD
Children's Hospital of Philadelphia

Panel:
Zuhair Ballas, MD
University of Iowa
Maite de la Morena, MD
University of Texas Southwestern Medical Center in Dallas
Imelda Celine Hanson, MD
Baylor College of Medicine
Ralph Shapiro, MD
Midwest Immunology Clinic
Troy Torgerson, MD, PhD
University of Washington
 
BOA D&E
3:00pm - 3:30pm Afternoon Break
 
BOA Foyer
3:30pm - 5:30pm Plenary Session: Hot New Defects
2 AMA PRA Category 1 Credits™
Moderator:

Thomas Fleisher, MD
NIH

Speakers:
Genetic Etiology of Life-Threatening Influenza
Michael Ciancanelli, PhD
The Rockefeller University

Genome Alterations in Human Immune Genetic Disorders: Mechanisms and Treatment
Michael Lenardo, MD
National Institute of Allergy and Infectious Diseases
National Institutes of Health

Novel Combined Immunodeficiencies
Emma Haapaniemi, MD
University of Helsinki
Luigi Notarangelo, MD
Boston Children's Hospital, Harvard Medical School

Oral Abstracts
NOVEL IL2Rα GENE MUTATIONS IN CD25 DEFICIENCY SYNDROME
Eleonora Gambineri, MD
University of Florence

NFKB2 MUTATION DISRUPTS CANONICAL AND NON-CANONICAL NF-κB SIGNALLING IN EARLY-ONSET COMMON VARIABLE IMMUNODEFICIENCY
Mohammad A. A. Ibrahim
King's College Hospital

A NEW GENETIC DISORDER PREDISPOSE MENDELIAN SUSCEPTIBILITY TO MYCOBACTERIAL DISEASES
Xiao-Fei Kong, MD, PhD
The Rockefeller University
 
BOA D&E
5:30pm - 5:45pm
 
Late Afternoon Break BOA Foyer
5:45pm - 6:30pm The Story of David the Bubble Boy
.75 AMA PRA Category 1 Credit™
Moderator:
Thomas Fleisher, MD
NIH

Speakers:
Carol Ann Demaret

William T. Shearer, MD, PhD
Baylor College of Medicine, Texas Children's Hospital
 
BOA D&E
6:30pm - 8:00pm CIS Closing Reception BOA A
     
Sunday, April 12    
7:00am - 8:00am Breakfast
 
BOA Foyer
8:00am - 10:00am PIDTC Session
2 AMA PRA Category 1 Credits™
Moderator:

Mort Cowan, MD
University of California, San Francisco

Speakers:
PIDTC 6902: Retrospective Study of Severe Combined Immunodeficiency in North America
Mort Cowan, MD
University of California, San Francisco

PIDTC 6901: The Modern State of SCID Diagnosis and Treatment
Chris Dvorak, MD
University of California, San Francisco

PIDTC 6903: Transplantation for Chronic Granulomatous Disease
Elizabeth Kang, MD
NIAID, NIH

PIDTC 6904: Prospective and Retro WAS Study
Luigi Notarangelo, MD
Boston Children's Hospital, Harvard Medical School
 
BOA D&E
     

*Speakers and Sessions Subject to Change.

2015 Annual Meeting Program Committee
Co-Chairs:
Donald B. Kohn, MD - University of California, Los Angeles
Luigi D. Notarangelo, MD - Children's Hospital, Harvard Medical School

Committee:
Roshini Sarah Abraham, PhD - Mayo Clinic
Jean-Laurent Casanova, MD PhD - The Rockefeller University
Elena Hsieh, MD - Stanford University
Steven M. Holland, MD - NIAID, NIH
Caroline Kuo, MD - UCLA Medical Center
Jordan S. Orange, MD PhD – Baylor College of Medicine
John M. Routes, MD - Medical College of Wisconsin
Mikko Seppänen, MD PhD - Helsinki University Central Hospital