CIS
CIS

Clinical Immunology Society (CIS)

2015 Annual Meeting: Immune Deficiency and Dysregulation North American Conference

2015 Update in Primary Immunodeficiency Diseases

April 9, 2015
Hilton Americas, Houston, TX
Agenda*

The majority of the sessions will be held on Level Two in the Ballroom of the Americas. Please note that it will abbreviated below as "BOA".

Thursday, April 9    
7:00am - 8:00am Breakfast
 
BOA Foyer
8:00am - 10:00am Welcome                                            
Charlotte Cunningham-Rundles
Mt Sinai Medical Center

 
BOA D&E
 

New Diseases
2 AMA PRA Category 1 Credits™
Moderator:
Troy Torgerson, MD, PhD
University of Washington

Speakers:
CTLA4 Haploinsufficiency and Immunedysregulation
Gulbu Uzel, MD
NIH


STAT3 Gain-of-Function: A New Syndrome of Early-Onset Autoimmunity
Megan Cooper, MD, PhD
Washington University

Primary NLRC4-Mediated Disorders
Neil Romberg, MD
Yale University

Oral Abstracts
INHERITED IL23R DEFICIENCY CAUSES MYCOBACTERIAL DISEASE
Janet Markle, PhD
The Rockefeller University

TRIPEPTIDYL PEPTIDASE II MUTATIONS CAUSE A HUMAN METABOLIC IMMUNODEFFICIENCY
Helen C. Su, MD, PhD
NIAID, NIH

COMBINED IMMUNODEFICIENCY ASSOCIATED WITH HOMOZYGOUS MALT1 MUTATIONS
Stuart E. Turvey, MD, PhD
British Columbia Children's Hospital

 

BOA D&E
10:00am - 10:30am Morning Break / Discussion
 
BOA Foyer
10:30am - 11:50am Focus on Therapeutics
1 AMA PRA Category 1 Credit™
Moderator:
Donald B. Kohn, MD
University of California, Los Angeles

Speakers:
Modulating STAT3 Proteostasis to Treat Immunodeficiency Disorders
David Tweardy, MD
Baylor College of Medicine

IL-7 Immunotherapy in Idiopathic CD4 Lymphopenia
Irini Sereti, MD
NIAID, NIH

CVID Therapeutics
John Routes, MD
Medical College of Wisconsin

IL-12 Mediated Gastrointestinal Disorder in Common Variable Immune Deficiency
Ivan Fuss, MD
NIH

Oral Abstract
GENE THERAPY FOR ADENOSINE DEAMINASE-DEFICIENT SEVERE COMBINED IMMUNE DEFICIENCY (ADA-SCID)
Donald B. Kohn, MD
University of California, Los Angeles

 
BOA D&E
11:50am - 12:30pm Guided Poster Session
Group 1
Moderator:
Roshini Sarah Abraham, PhD
Mayo Clinic

NEWBORN SCREENING BEYOND TRECs AND KRECs: REACHING OUT FOR PHAGOCYTIC DEFECTS, COMPLEMENTS AND ANTIBODY DEFICIENCIES AND NEXT-GEN SEQUENCING
Stephan Borte, MD, PhD
Translational Centre for Regenerative Medicine Leipzig

CYTOMETRY BASED SCREENING FOR GAIN-OF-FUNCTION MUTATION IN SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1 (STAT1-GOF)
David Hagin, MD, PhD
University of Washington, Seattle Children's Hospital

ADULT ONSET MYCOBACTERIAL INFECTION DUE TO NON-CODING MUTATIONS IN IKBKG AFFECTING NEMO PROTEIN LEVELS
Amy P. Hsu, BA
NIAID

PERFORIN-2 MUTATIONS IN PULMONARY NONTUBERCULOUS MYCOBACTERIAL INFECTION
Ryan McCormack, BS
University of Miami

PRELIMINARY DATA FOR mTOR INHIBITOR TREATMENT IN PATIENTS WITH OF GAIN-OF-FUNCTION MUTATIONS IN PIK3CD
Kelli W. Williams, MD, MPH
NIAID, NIH

Group 2
Moderator:
Troy Torgerson, MD, PhD
University of Washington

PATIENTS WITH CARTILAGE-HAIT HYPOPLASIA DISPLAY TELOMERE LENGTH DEFICIENCY COMPARED TO RMRP MUTATION HETEROZYGOTES AND NORMAL CONTROLS
Geraldine Aubert, PhD
BC Cancer Research Centre

SMITH MAGENIS SYNDROME: CLINICAL IMMUNOLOGIC FEATURES OF 70 PATIENTS CARRYING A SINGLE TACI ALLELE
Tiffany Perkins, MD
Yale New Haven Hospital

ESTIMATED DISEASE INCIDENCE OF RAG1 MUTATION BY QUERYING THE EXOME AGGREGATION CONSORTIUM
Jolan E. Walter, MD, PhD
Boston Children's Hospital

TREATMENT OF CHRONIC GRANULOMATOUS DISEASE ASSOCIATED COLITIS WITH ANAKINRA
Christa S. Zerbe, MD
NIAID, NIH
 
BOA A-C
12:30pm - 1:30pm Lunch / Poster Viewing / Exhibit Hall Open
 
BOA A-C
1:30pm - 2:40pm Misguided Cells
1 AMA PRA Category 1 Credit™
Moderator:
Vincent Bonagura, MD
Steven and Alexandra Cohen Children's Medical Center of New York

Speakers:
IgG4-Related Disease: How did we miss this for so long?
John Stone, MD, MPH
Massachusetts General Hospital

Troy Torgerson, MD, PhD
University of Washington

Inflammatory Innate Lymphoid Cells in CVID
Charlotte Cunningham-Rundles, MD, PhD
Mt Sinai Medical Center

Oral Abstract
:
DOCK8 REGULATES LYMPHOCYTE MIGRATION AND INFLUENCES THE CYTOSKELETON THROUGH DIVERSE RHO GTPASE FAMILY EFFECTORS
Heardley Murdock, BS
NIAID, NIH
 
BOA D&E
2:45pm - 3:00pm Afternoon Break
 
BOA Foyer
3:00pm - 5:00pm Responding to the World Around Us
2 AMA PRA Category 1 Credits™
Moderator:
Steven M. Holland, MD
NIAID, NIH

Speaker:
Responses to Bacteria in Patients with MYD88 or IRAK4 Deficiencies
Laia Alsina, MD, PhD

Hospital Sant Joan de Déu, Barcelona

Off-Target Benefits of Vaccination
Tobias Kollmann, MD, PhD
University of British Columbia


Oral Abstracts:
THE MUTATIONAL DAMAGE LANDSCAPE ACROSS THE HUMAN GENOME: A GENE-LEVEL APPROACH TO THE SELECTION OF CANDIDATE DISEASE-CAUSING VARIANTS
Yuval Itan, PhD
The Rockefeller University

MANIPULATING DNA DAMAGE RESPONSE PATHWAYS FOR THE TREATMENT OF IMMUNE DISEASES
Michael B. Jordan, MD
Cincinnati Children's Hospital Medical Center

Speaker:
Immune System Dysregulation Persists During Long-Duration Spaceflight
Brian Crucian
NASA

 
BOA D&E
5:00pm - 5:30pm Richard Schiff Lecture
.5 AMA PRA Category 1 Credit™
Moderator:
Jordan S. Orange, MD, PhD
Baylor College of Medicine

Speaker:
Unlocking Secrets from Cryopreserved Cells
Rebecca Buckley, MD
Duke University
BOA D&E

*Speakers and Sessions Subject to Change.

Program Description
Derived from the need to understand how to treat primary immune deficiency diseases in the context of other diseases, the CIS developed the Update in Primary Immunodeficiency Diseases which is geared toward physicians and scientists who are involved in the evaluation and/or care of patients with primary immune deficiencies.

Learning Objectives
Provide advanced training for physicians and researchers working in the field of primary immune deficiency that covers diagnosis, therapy and future trends related to the care of patients with primary immune deficiencies.

•      Facilitate interactions among clinicians of diverse training to promote multicenter clinical trials and to coordinate participation in existing clinical trials.

•      Improve recognition of primary immune deficiencies.

•      Improve understanding of the diagnostic issues and the pathophysiology of primary immune deficiencies.

•      Improve understanding of the appropriate interventions for these diseases.

Target Audience
This program is designed for allergist-immunologists, primary care physicians, nursing professionals specializing in immunology and other medical professionals who treat primary immunodeficiency diseases.