CIS

Clinical Immunology Society (CIS)

2016 Annual Meeting: Immune Deficiency and Dysregulation North American Conference

Final Program Now Available! Click here to download.

*Sessions and speakers subject to change

Thursday, April 14    
6:00pm - 6:10pm Welcome from CIS President
Luigi D. Notarangelo, MD
Children's Hospital Boston
 
 
6:10pm - 7:00pm

Robert A. Good Lecture
.75 AMA PRA Category 1 Credits™
Moderator:
Luigi D. Notarangelo, MD
Children's Hospital Boston
Speaker:
Immune Response Genes and Human Diseases
Alain Fischer, MD, PhD
The Imagine Institute

 
7:00pm - 8:30pm Opening Reception
 
 
Friday, April 15    
8:00am - 10:00am

Immune Dysregulation
2 AMA PRA Category 1 Credits™
Moderators:
Troy R. Torgerson, MD, PhD
Seattle Children's Hospital

Jolan Walter, MD, PhD
Massachusetts General Hospital

Speakers:
What's New Up in the Aire
Mark Anderson, MD, PhD
University of California, San Francisco

APECED in North America: A syndrome highly-enriched for non-endocrine
autoimmune manifestations
Mihalis Lionakis, MD, ScD
National Institutes of Health

Age-Related Immune Dysregulation
Diane Mathis, PhD
Harvard Medical School

Metabolic View of the Immune System
Talal Chatila, MD, PhD
Children's Hospital Boston

Oral Abstract
IDENTIFICATION OF TYPE I INTERFERONOPATHIES IN CHILDREN
WITH EARLY-ONSET SLE AND VASCULOPATHY
Stefano Volpi, PhD
University Hospital of Lausanne
 

 
10:00am - 11:00am Morning Break & Guided Poster Sessions
Moderator:
Roshini Sarah Abraham, PhD
Mayo Clinic
Group 1

ALTERED INVARIANT NKT:B CELL HELP AND DECREASED SAP
EXPRESSION IN BLOOD LYMPHOCYTES FROM PATIENTS WITH
COMMON VARIABLE IMMUNODEFICIENCY

Lucia Erazo Borras, MSc
University of Antioquia

FATAL HYPERINFLAMMATION IN MURINE MODEL OF LEAKY
SCID/OMENN SYNDROME: INNATE OVERACTIVATION LOCALIZED
IN SMALL AND LARGE INTESTINES

Krisztian Csomos, PhD
Massachusetts General Hospital Harvard Medicine School

IMPAIRED RASGRF1/ERK-MEDIATED GM-CSF RESPONSE
CHARACTERIZES CARD9 DEFICIENCY IN FRENCH-CANADIANS

Donald C. Vinh, MD
McGill University Health Centre-Research Institute

EXOSTOSIN-LIKE GLYCOSYL TRANSFERASE 3 (EXTL3) GENE
MUTATION CAUSES A NOVEL FORM OF IMMUNO-OSSEOUS
DYSPLASIA AND UNVEILS A CRITICAL ROLE OF HEPARAN SULFATE
IN THYMOPOIESIS

Stefano Volpi, PhD
Boston Children's Hospital

Moderator:
Tamara Pozos, MD, PhD
Children's Hospitals & Clinics of Minnesota
Group 2

APOPTOSIS RESISTANCE AND INTRINSIC DIFFERENTIATION
DEFECTS IN ACTIVATED BENTA PATIENT B CELLS

Andrew L. Snow, PhD
Uniformed Services University of Health Sciences

INFLUENCE OF BAFF/BAFF-R AXIS UPON COMMON VARIABLE
IMMUNODEFICIENCY INTERSTITIAL LUNG DISEASE

Paul J. Maglione, MD, PhD
Icahn School of Medicine at Mount Sinai

A PATHOGENEIC HYPOMORPHIC MUTATION IN LRRC8A IMPAIRS
VOLUME REGULATED ANION CHANNEL ACTIVITY BUT SPARES
T CELL DEVELOPMENT AND FUNCTION

Craig D. Platt, MD, PhD
Boston Children's Hospital, Harvard Medical School

LONG-TERM IMMUNE RECONSTITUTION POST-HEMATOPOIETIC
STEM CELL TRANSPLANTATION IN IL2RG/JAK3, SCID,
NEWCASTLE EXPERIENCE
Intan Juliana Abd Hamid
Institute of Cellular Medicine, Newcastle University

NK CELLS FROM PATIENTS WITH RAG AND ARTEMIS DEFICIENCY
HAVE AN IMMATURE PHENOTYPE AND DISPLAY INCREASED
DEGRANULATION CAPACITY – IMPLICATIONS FOR HEMATOPOIETIC
CELL TRANSPLANTATION

Luigi D. Notarangelo, MD
Boston Children's Hospital
 
 
11:00am - 12:30pm Tales from the Listserv
1.5 AMA PRA Category 1 Credits™
Moderators:
Elie Haddad, MD, PhD
CHU Ste-Justine, University of Montreal
Mikko Seppänen, MD, PhD
Helsinki University Central Hospital

Mystery Case #1
Joshua D. Milner, MD
NIH/NIAID

Mystery Case #2
Juan Carlos Aldave, MD
Hospital Nacional Edgardo
 
 
12:30pm - 1:45pm Lunch / Poster Viewing / Exhibit Hall Open
 
 
1:45pm - 3:45pm

Cell Perturbation & Plasticity in the Immune System
2 AMA PRA Category 1 Credits™
Moderators:

Jordan Orange, MD, PhD  
Baylor College College of Medicine
Emily Mace, PhD
Baylor College of Medicine

Speakers:
Very Early Onset Inflammatory Bowel Disease – From Genes
to Function
Scott B. Snapper, MD
Children's Hospital Boston

Imaging Immunity: Creating a Spatiotemporal Understanding
of Host Defense
Ronald N. Germain, MD, PhD
National Institutes of Health

Dissecting the Heterogeneity of Human Memory T Helper Cells
Federica Sallusto, PhD
Institute for Research in Biomedicine

Mitophagy Promotes the Generation of Natural Killer Cell Memory
Joseph Sun, PhD
Memorial Sloan Kettering Cancer Center

 
3:45pm - 4:15pm Afternoon Break
 
 
4:15pm - 5:45pm

Gene Therapy/Editing
1.5 AMA PRA Category 1 Credits™
Moderators:
Caroline Kuo, MD
UCLA Medical Center
David Hagin, MD, PhD
University of Washington/Seattle Children's Hospital

Speakers:
Efficacy and Safety of gene therapy approach to
Wiskott-Aldrich Syndrome and X-linked Severe
Combined Immunodeficiency
David A. Williams, MD

Children's Hospital Boston

Gene Therapy for ADA-Deficient SCID and X-linked Chronic
Granulomatous Disease

Donald B. Kohn, MD
University of California, Los Angeles

Breaking Bad: Genome-wide Detection of Designer Nuclease
Targeting and its Ensuing Collateral Damage
Richard Frock, PhD
Children's Hospital Boston

Oral Abstracts
TARGETED GENE EDITING RESTORES REGULATED CD40L
EXPRESSION AND FUNCTION IN X-HIGM T CELLS

Nicholas W. Hubbard
Seattle Children's Research Institute

REVERSING EPIGENETIC GENE SILENCING IN COMMON
VARIABLE IMMUNODEFICIENCY

M. Julia B. Felippe, MedVet, MS, PhD, DACVIM
Cornell University College of Veterinary Medicine

 
5:45pm - 6:00pm Late Afternoon Break
 
 
6:00pm - 7:00pm The CIS Fahey/Rose Founders Lecture
1 AMA PRA Category 1 Credits™
Moderator:
Luigi D. Notarangelo, MD
Children's Hospital Boston
Speaker:
Emerging Infectious Diseases
Steven M. Holland, MD
NIAID, NIH
 
 
7:15pm - 8:45pm Measuring Quality, Patient-Centered Outcomes and
Special Populations in Primary Immunodeficiencies

1.5 AMA PRA Category 1 Credits™
Moderator:
Kathleen E. Sullivan, MD, PhD
Children's Hospital of Philadelphia

Speakers:
Disease-Specific Health-Related Quality of Life Outcomes in Patients
with Antibody Immune Deficiency
Mark Ballow, MD, FAAAAI
University of South Florida

Primary Immunodeficiencies in the Old Order
Amish & Mennonite Communities
Nicholas L. Rider, DO
Baylor College of Medicine

SCID in the Navajo: A Founder Population in the US
Jennifer M. Puck, MD
University of California, San Francisco

Latin American Challenges with Diagnoses and
Treatment of PID
Beatriz Costa-Carvalho, MD
Federal University of Sao Paulo, Brazil

Supported by an Educational Grant from Baxalta.
 
 
Saturday, April 16    
8:00am - 9:30am HCT in PID - Old & New Indications
1.5 AMA PRA Category 1 Credits™
Moderators:
Donald Kohn, MD
University of California, Los Angeles
Jennifer Heimall, MD
The Children's Hospital of Philadelphia

Speakers:
The Primary Immune Deficiency Treatment Consortium:
How Can it Improve Definitive Therapy for PID?
Morton J. Cowan, MD
University of California, San Francisco

Transplanting New Indications: NEMO Deficiency
Bertrand Boisson, PhD
The Rockefeller University

HSCT for STAT3 and CTLA4 Deficiency – Why, How and When
Andrew Gennery, MD
Newcastle University

STAT1 GOF
Jen Leiding, MD
University of South Florida

STAT3 GOF
Lisa Forbes, MD
Baylor College of Medicine

Oral Abstracts
A SINGLE CENTRE COHORT REPORT OF LONG TERM CLINICAL
OUTCOME OF SEVERE COMBINED IMMUNODEFICIENCY
FOLLOWING HAEMATOPOIETIC STEM CELL
TRANSPLANTATION

Intan Juliana Abd Hamid
Institute of Cellular Medicine, Newcastle University

A PROSPECTIVE ALEMTUZUMAB PHARMAKOKINETIC (PK)
STUDY REVEALS THAT PERI-TRANSPLANT ALEMTUZUMAB
LEVELS DEPEND ON ABSOLUTE LYMPHOCYTE COUNT AND
UNDERLYING PRIMARY IMMUNE DEFICIENCY

Rebecca Marsh, MD
Cincinnati Children's Hospital Medical Center
 
 
9:30am - 10:15am CIS Business Meeting & Award Presentations
 
 
10:15am - 11:15am Morning Break & Guided Poster Sessions
Moderator:
Roshini Sarah Abraham, PhD
Mayo Clinic
Group 1

HUMAN T FOLLICULAR HELPER CELLS IN PRIMARY
IMMUNODEFICIENCY: QUALITY JUST AS
IMPORTANT AS QUANTITY

Cindy S. Ma, PhD
Garyan Institute of Medical Research

DEFECTS IN HUMAN B-CELL DEVELOPMENT AND
DIFFERENTIATION DUE TO DISEASE-CAUSING MUTATIONS
IN THE PI3K PATHWAY

Elissa Deenick
Garvin Institute of Medical Research

NOVEL STAT1 GOF MUTATION AFFECTING
PROTEIN SUMOYLATION

Elizabeth P. Sampaio, MD, PhD
NIAID/NIH

A NOVEL DONOR SPLICE-SITE MUTATION CAUSING
CTLA4 HAPLO-INSUFFICIENCY AND SEVERE AUTOIMMUNITY

David Hagin, MD, PhD
University of Washington/Seattle Children's Hospital

Moderator:
Tamara Pozos, MD, PhD
Children's Hospitals & Clinics of Minnesota
Group 2

SELECTIVE DEFICIENCY OF WASP IN TREG CELLS IS
SUFFICIENT TO CAUSE AUTOIMMUNITY IN MICE

Stefano Volpi, PhD
University Hospital of Lausanne

IMMUNODEFICIENCY SYNDROME ASSOCIATED WITH
HAPLOINSUFFICIENCY OF NFKB1 SUBUNIT p50:
REPORT OF 5 IDENTIFIED CASES

Elizabeth Feuille, MD
Icahn School of Medicine at Mount Sinai

MULTI-LINEAGE ANALYSIS OF X-INACTIVATION IN 54
FEMALES CARRIER OF GENETIC ALTERATIONS IN THE
WISKOTT-ALDRICH SYNDROME PROTEIN (WASP) GENE LOCUS

Daniele Moratto
University of Brescia

X-LINKED CARRIERS OF CHRONIC GRANULOMATOUS DISEASE
Betty Marciano, MD
NIAID/NIH
 
 
11:15am - 12:45pm Plenary Session: Antibody Deficiencies
1.5 AMA PRA Category 1 Credits™
Moderators:
Vincent Bonagura, MD
Editor-in-Chief, Journal of Clinical Immunology
Joyce Yu, MD
Morgan Stanley Children's Hospital/Columbia University Medical

Speakers:
The Pathogenesis of IgG4-related disease
Shiv Pillai, MD, PhD
Harvard Medical School

Shutting off Autoimmunity with anti-CD21 Therapy
Michael C. Carroll, MD, PhD
Children's Hospital Boston

Defects in Transcription Factors Resulting in Antibody Deficiency 
Mary Ellen Conley, MD
The Rockefeller University

S-6-Kinopathies
Bodo Grimbacher, MD
University of Freiburg

Oral Abstract
RITUXIMAB AND HYPOGAMMAGLOBULINEMIA –
COMPARATIVE OUTCOMES AT MASSACHUSETTS
GENERAL HOSPITAL

Sara Barmettler, MD
Massachusetts General Hospital
 
 
12:45pm - 1:45pm Lunch / Poster Viewing / Exhibit Hall Open
 
 
1:45pm - 3:15pm Immunoglobin: What it Can and Can't Do
1.5 AMA PRA Category 1 Credits™
Moderators:
Charlotte Cunningham-Rundles, MD, PhD
Mount Sinai Medical School
Kathleen E. Sullivan, MD, PhD
Children's Hospital of Philadelphia

Panelists:
Zuhair Ballas, MD
University of Iowa Healthcare

Francisco Bonilla, MD, PhD
Children's Hospital Boston

Kenneth Paris, MD
LSU Health Sciences Center
 
 
3:15pm - 3:45pm Afternoon Break
 
 
3:45pm - 5:45pm

T Cell Ontogeny/Development in Health and Disease
2 AMA PRA Category 1 Credits™
Moderators:
Jennifer Puck, MD
University of California, San Francisco
Shanmuganathan Chandrakasan, MD
Emory University School of Medicine, Children's Healthcare of Atlanta

Speakers:
Development Cues in Thymopoiesis
Georg Holländer, MD
University of Basel, Switzerland

Immune reconstitution after transplantation in SCID:
what we know and what we would like to know
Elie Haddad, MD, PhD
CHU Ste-Justine, University of Montreal

Following Infants with Low (T Cell) Lymphocytes:
FILL Project
John M. Routes, MD
Medical College of Wisconsin

A Patient with a CD4 Gene Mutation and Immunodeficiency
Jose Luis Franco, MD, PhD
University of Antioguia

 
5:45pm - 6:45pm

Richard Schiff Lecture
1 AMA PRA Category 1 Credits™
Moderator:
Jordan Orange, MD, PhD
Baylor College of Medicine

Speaker:
An Approach to Novel Immune Deficiencies
Raif Geha, MD
Children's Hospital Boston
 

 
6:45pm - 8:30pm CIS Closing Reception
 
 
Sunday, April 17    
8:00am - 10:00am Hot New Defects!
2 AMA PRA Category 1 Credits™
Moderator:
Magda Carneiro-Sampaio, MD, PhD
Universidade De Sao Paulo

Speakers:
Sergio D. Rosenzweig, MD
NIAID, NIH

Jean-Laurent Casanova, MD, PhD
The Rockefeller University

Kaan Boztug, MD
Medical University of Vienna

Oral Abstracts
NOVEL IMMUNODYSREGULATION DISORDER CAUSED
BY LOSS-OF-FUNCTION MUTATIONS IN SBNO2

Huie Jing, PhD
National Institute of Allergy and Infectious Diseases

RUBELLA VIRUS IN CUTANEOUS GRANULOMAS IN
IMMUNE DEFICIENT PATIENTS

Kathleen Sullivan, MD, PhD
Children's Hospital of Philadelphia
 
 
10:00am - 12:00pm Plenary Session: Hot New Treatments!
2 AMA PRA Category 1 Credits™
Moderator:
Andrew Gennery, MD
Newcastle University

Speakers:
Treatment of Treg-opathies: LRBA, CTLA4, and other genetic lesions
Michael B. Jordan, MD
Cincinnati Children's Hospital Medical Center

JAK1 Inhibitors
Raphaela Goldbach-Mansky, MD
NIAMS, NIH

Understanding Immune Function Through Primary
Immunodeficiency Diseases
Michael Lenardo, MD
NIH

Oral Abstracts
TREATMENT WITH IL-6 BLOCKADE IN PATIENTS WITH
GAIN OF FUNCTION STAT3 MUTATIONS

Johana B. Castro-Wagner, MD
University of Florida/All Children's Hospital

A NOVEL TARGETED APPROACH TO THE TREATMENT OF
HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS (HLH) WITH
NI-0501, AN ANTI-INTERFERON GAMMA MONOCLONAL ANTIBODY

Michael B. Jordan, MD
Cincinnati Children's Hospital Medical Center

CLINICAL SPECTRUM AND OUTCOME OF TREATMENT
FOR AUTOIMMUNE CYTOPENIAS IN RAG DEFICIENCY

Zsofia Foldvari, MD
University of Debrecen