2019 Annual Meeting

Dear Colleagues,

On behalf of the Clinical Immunology Society (CIS), thank you for participating in the 2019 Annual Meeting: Immune Deficiency & Dysregulation North American Conference taking place April 4-7, 2019 at the Marriott Marquis in Atlanta, Georgia.

 

CIS is the key multidisciplinary organization for the field of clinical immunology, and is

devoted to fostering developments in the science and practice of clinical immunology. The mission of CIS is to facilitate education, translational research and novel approaches to therapy in clinical immunology, and to promote excellence in the care of patients with immunologic/inflammatory disorders...

 

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SPECIAL SYMPOSIUM - Thymic Defects: From Biology to Treatment

CIS will be holding a symposium, Thymic Defects: From Biology to Treatment, on Wednesday, April 3rd, prior to the Annual Meeting. This program will focus on the many aspects of thymic biology, associated diseases, and optimal treatment options.

 

Registration is open to anyone, although space is limited to the first 100 individuals. There is a $100 additional fee to attend the symposium. Please note: this symposium will be held at the Hilton Atlanta, which is across the street from the Marriott Marquis.

View the Agenda

 

*If you have already registered for the Annual Meeting and are interested in registering for this program, please contact the CIS office at info@clinimmsoc.org.

 

**HOTEL RESERVATIONS—The Marriott Marquis is currently sold out for the night of April 2nd. CIS will update this section if rooms do become available. Hotel rooms near the Marriott and Hilton are limited due to other events in Atlanta.


Pre-Conference Education Day

PID & ID Diagnosis, Management and Publishing Case Reports 

The 2019 pre-conference, held on Thursday, April 4, will be an education day focused on case-based learning and discussion among attendees focused on primary immunodeficiency and immunedysregulation diagnosis and management. Featuring a mix of master classes and abstract case presentations, as well as an in-depth discussion on publishing case reports, this session will provide an excellent venue for clinically oriented case discussions and lectures.


*Please note, there will be an additional registration fee to attend the Education Day.

 

VIEW DRAFT AGENDA


 

Annual Meeting Program

The 2019 Annual Meeting will officially begin on Thursday, April 4th following the conclusion of the Pre-Conference Education Day.

Open AllClose All
  Thursday, April 4

8:00am - 2:00pm

Pre-Conference Education Day (Additional Registration Fee Required)

 

2:15pm - 2:30pm

Opening and Welcome to the 2019 CIS Annual Meeting

Roshini Sarah Abraham, PhD, CIS President, Nationwide Children's Hospital

 

2:30pm - 4:30pm

Plenary Session #1: Immune Dysregulation   

2 AMA PRA Category 1 Credits TM    

Moderators:

Jolan Walter, MD, PhD, University of South Florida

Kiran Patel, MD, Emory University

 

Speakers:

Immune dysregulation observed in Patients with Hypomorphic RAG Defects
Luigi Notarangelo, MD, National Institutes of Health

 

The paradox of immune deficiency and autoimmunity due to PIK3CD GOF mutations
Stuart Tangye, PhD, Garvan Institute              

 

Update on CARD11 Defects: From BENTA to Atopy and Beyond
Andrew Snow, PhD, Uniformed Services University of the Health Sciences

 

Oral Abstracts

Application of Targeted Proteomics in the Diagnosis and Screening of Primary Immunodeficiency Disorders
Christopher Collins, PhD, Seattle Children's Hospital

 

Heterozygous OAS1 Mutations Cause Spontaneous RNA Cleavage and Apoptosis with Resulting Multisystem Inflammation and Immunodeficiency
Jennifer Heimall, MD, Children’s Hospital of Philadelphia

 

 

4:30pm - 5:30pm 

Robert A. Good Lecture

1 AMA PRA Category 1 Credits TM 

Moderator:

Jordan Orange, MD, PhD, Columbia University

 

Speaker:

Refusal of Vaccination: Implications for Immunodeficient Patients In The Community
Peter Hotez, MD, PhD, Baylor College of Medicine

 

5:30pm - 6:50pm 

Plenary Session #2: Opening Plenary: Fellowship Presentations & Notable Abstracts

1.5 AMA PRA Category 1 Credits TM 

Moderators:

Linda Griffith, MD, PhD, DAIT, NIAID, NIH

Caroline Kuo, MD, UCLA Medical Center

 

Speaker:

Correcting Genetic Defects Associated with Severe Combined Immunodeficiency (30’)
David Nguyen, MD, PhD, UCSF

 

Oral Abstracts

Lentiviral Vector Gene Therapy for X-linked Chronic Granulomatous Disease Corrects Neutrophil Function
Harry Malech, MD, NIH


Novel Compound Heterozygous Mutations in Forkhead Box N1 (FOXN1) Cause a Severe Immunodeficiency Without Alopecia or Nail Dystrophy
Nicolai Van Oers, PhD, UT Southwestern

 

Investigational Cultured Thymus Tissue Transplantation (RVT-802) Following Failed Stem Cell Transplantation in Athymic Patients
Tyler Yates, MD, Duke University

 

Low Dose Azithromycin Prophylaxis Reduces Respiratory Exacerbations in Patients Affected by Primary Antibody Deficiencies : A Multicenter, Double-blind, Placebo-controlled Randomized Clinical Trial
Cinzia Milito, MD, PhD, Sapienza University of Rome

 

6:50pm - 7:00pm

Tribute to Dr. William Shearer

Jordan Orange, MD, PhD, Columbia University

 

7:00pm - 7:45pm 

Mentor-Mentee Reception

 

7:45pm - 9:00pm 

 

Early Career Immunologist Reception

 

  Friday, April 5

7:00am - 8:00am

Continental Breakfast

 

7:00am - 8:00am

Diagnostic Genomics 101 (Additional Registration Fee Required)

1 AMA PRA Category 1 Credits TM 

Janet Chou, MD, Boston Children's Hospital
Helen Su, MD, PhD, NIH

 

8:00am - 9:30am

Plenary Session #3: Cross-Talk: PIDs from the Perspective of Other Specialties

1.5 AMA PRA Category 1 Credits TM 

Moderators:

Nicholas Rider, DO, Baylor College of Medicine
Alexandra Freeman, MD, NIH

 

Speakers:

Endocrine Issues In Patients With Immunological Diseases        
Maureen Su, MD, UCLA

 

Genetics/Undiagnosed Diseases Program Update    
William Gahl, MD, PhD, National Institutes of Health

 

Pulmonary alveolar proteinosis: A primary and secondary disease 
Bruce Trapnell, MS, MD, Cincinnati Children’s Hospital Medical Center

 

Oral Abstracts

CARD9del11 Gene Dosage: From Mono-allelic Protection to IBD, to Bi-allelic Increased Fungal Infection Susceptibility
Shubham Goel, PhD, NIH

 

A 30-year Prospective Study Reveals Risk Factors for Malignancies and Early Death in Cartilage-hair Hypoplasia
Svetlana Vakkilainen, MD, Univeristy of Helsinki, HUS Helsinki University Hospital, and Folkhälsan Institute of Genetics

 

Natural History of Anti-Interferon-gamma Autoantibody-associated Immunodeficiency Syndrome in Thailand
Gloria Hong, BA, NIAID, NIH

 

9:30am - 10:00am

Morning Break

 

10:00am - 11:30am

Plenary Session #4: Cross-Talk: PIDs from the Perspective of Other Specialties II

1.5 AMA PRA Category 1 Credits TM 

Moderators:

Surjit Singh, MD, Postgraduate Institute of Medical Education and Research, Chandigargh, India
Elena Hsieh, MD, University of Colorado Denver

 

Speakers:

NICER and the opportunities for immunohematology/oncology
Kelly Walkovich, MD, CS Mott’s Children’s Hospital

 

Fecal Microbiome Transplants
Stacy Kahn, MD, Boston Children’s Hospital

 

Oral Abstracts:

Immunophenotype and Metabolic Characteristics of EBV-Specific T Cells Generated Using Different Manufacture Approaches
Danielle Arnold, MD, Children’s Hospital of Philadelphia

 

Evaluation of Persistent Hypogammaglobulinemia Post-rituximab in Patients Undergoing HSCT for XLP-1 Reveals Preserved Ability of B-cells to Class-switch and Differentiate to Plasmablasts In-vitro
Shan Chandrakasan, MD, Children’s Healthcare of Atlanta, Emory University

 

Emapalumab-lzsg for the Treatment of Pediatric Patients with Primary Hemophagocytic Lymphohistiocytosis
Michael Jordan, MD, Cincinnati Children’s Hospital Medical Center

 

11:30am - 1:30pm

Lunch/Exhibit Hall Open

 

12:00pm - 12:30pm

Lightning Poster Presentations

Moderators:

Troy Torgerson, MD, PhD, University of Washington/Seattle Children's Research Institute
Rebecca Marsh, MD, Cincinnati Children's Hospital Medical Center

 

Presenters:

Epigenetic Immune Cell Quantification for Diagnosis and Monitoring of Patients with Primary Immune Deficiencies and Immune Regulatory Disorders    
Janika Schulze, MSc, Epimune GmbH

 

Characterization of Gut Inflammation and Autoimmunity in Mice Carrying Rag1 Hypomorphic Mutations
Riccardo Castagnoli, MD, NIAID

 

Quercetin Halts Abnormal IL-1beta and IL-18 Production: A Natural Calm for XIAP Deficiency?    
Erika Owsley, Cincinnati Children’s Hospital Medical Center

 

Hyperactivated PI3Kd Promotes Self and Commensal Reactivity at the Expense of Optimal Humoral Immunity
Silvia Preite, PhD, NHGRI

 

Clinical Phenotyping of a DOCK8 Deficiency Cohort    
Alexandra Freeman, MD, NIH

 

12:30pm - 1:30pm

Poster Session I

 

1:30pm - 3:00pm

Plenary Session #5: Tales from the Listserv

1.5 AMA PRA Category 1 Credits TM 

Moderators:

Elie Haddad, MD, PhD, University of Montreal/CHU-Ste. Justine
Mikko Seppänen, MD, PhD, Helsinki University Central Hospital
Eric Allenspach, MD, PhD, University of Washington & Seattle Children's Hospital

 

Speakers:

Mystery Case #1
David Hagin, MD, PhD, Tel-Aviv Sourasky Medical Center

 

Mystery Case #2
Elizabeth Feuille, MD, Weill Cornell Medicine

 

Mystery Case #3
Christopher Chang, MD, PhD, MBA, Joe DiMaggio Children's Hospital

 

3:00pm - 3:30pm

Afternoon Break

 

3:30pm - 4:30pm

Roundtable Breakout Discussions

1 AMA PRA Category 1 Credits TM 

Transplantation:

Andrew Cant, MD, Newcastle General Hospital
Mort Cowan, MD, UCSF Benioff Children's Hospital

 

Gene Therapy:

Don Kohn, MD, University of California, Los Angeles
Adrian Thrasher, MD, PhD, UCL Great Ormond Street Institute of Child Health

 

Diagnostic Work-Up of PIDs:

Sergio Rosenzweig, MD, PhD, NIH
Megan Cooper, MD, PhD, Washington University in St. Louis

 

4:30pm - 5:30pm

CIS Rose/Fahey Lecture

1 AMA PRA Category 1 Credits TM 

Moderator:

Sergio Rosenzweig, MD, PhD, NIH

 

Speaker:

Glycobiology and Immunology
Ajit Varki, MD, University of California, San Diego

 

5:30pm - 6:00pm

Plenary Session: PID Year in Review

.5 AMA PRA Category 1 Credits TM 

Moderators:

Prescott Atkinson, MD, PhD, FAAAAI, University of Alabama at Birmingham/Children's Hospital
Joe Church, MD, Children's Hospital of Los Angeles

 

Presenters:

Annaliese Blincoe, MD, Starship Children's Health

 

Karin Chen, MD, University of Utah

 

Cathleen Collins, MD, PhD, University of California, San Diego

 

Samuel Chiang, PhD, Cincinnati Children's Hospital Medical Center

 

6:30pm - 8:00pm

Women in Clinical Immunology Sciences Reception: Diversity and Implicit Bias in Academic Medicine

Sponsored by Horizon Pharma

Moderator:

Victoria Dimitriades, MD, University of California, Davis

 

Speaker:

Laura Castillo-Page, PhD, Association of American Medical Colleges
 

This reception is open to all Annual Meeting attendees!

 

  Saturday, April 6

7:00am - 8:00am

Continental Breakfast

 

7:00am - 8:00am

Functional Validation 102 (Additional Registration Fee Required)

1 AMA PRA Category 1 Credits TM 

Moderators:

Sarah Henrickson, MD, PhD, Children's Hospital of Philadelphia
Manish Butte, MD, PhD, University of California, Los Angeles

 

8:00am - 9:30am

Plenary Session #7: Therapeutic and Technological Frontiers

1.5 AMA PRA Category 1 Credits TM  

Moderators:

Neil Romberg, MD, Children's Hospital of Philadelphia
Tandakha Dieye, PhD, Université Cheikh Anta Diop, Senegal

 

Speakers:

Therapeutic Advances in Clinical Immunology/PIDs
Bodo Grimbacher, MD, University of Freiburg

 

Lab on a Chip to Screen for Infections in Resource-Poor Areas, Digital Microfluidics
Aaron Wheeler,  PhD, University of Toronto

 

Oral Abstract:

Lentiviral Gene Therapy Corrects Platelet Phenotype and Function in Wiskott-Aldrich Patients
Lucia Sereni, PhD, San Raffaele Telethon Institute for Gene Therapy (SR-Tiget)

 

9:30am - 10:30am

Plenary Session #8: Infections in PIDs

1 AMA PRA Category 1 Credits TM 

Moderator:

Maite de la Morena, MD, Seattle Children's Hospital
Francisco Espinosa, MD, Centro de Inmunología Alergia y Pediatría Hospital Ángeles Lomas

 

Speakers:

Unusual Fungal Infections in PIDs
Michail Lionakis, MD, ScD, NIAID

 

Rubella in Chronic Inflammation
Ludmila Perelygina, PhD, CDC

 

10:30am - 11:00am

Morning Break

 

11:00am - 11:30am

Plenary Session #9: Presidential Award Lecture

.5 AMA PRA Category 1 Credits TM  

Moderator:

Roshini Abraham, PhD, Nationwide Children's Hospital

 

Speaker:

EBV Infection and Susceptibility in Monogenic Immune Disorders
Stuart Tangye, PhD, Garvan Institute

 

11:30am - 1:30pm

Lunch/Exhibit Hall Open

 

11:30am - 12:30pm

Early Career Immunologist Luncheon: How to Carve a Niche and Lead

 

Speakers:

  • Thomas Fleisher, MD, AAAAI
  • Megan Cooper, MD, PhD, Washington University in St. Louis
  • Emily Mace, PhD, Baylor College of Medicine
  • Mark Ballow, MD, FAAAI, University of South Florida

 

12:00pm - 12:30pm

Lightning Poster Presentations

Moderators:

Troy Torgerson, MD, PhD, University of Washington/Seattle Children's Research Institute
Eleonora Gambineri, MD, University of Florence

 

Presenters:

Prevalence of Hypogammaglobulinemia in Newly Diagnosed Lymphoma
Namrata Singh, MD, MSCI, FACP, University of Iowa Hospitals and Clinics


Hexaviral-Specific T-cells for Treatment and Prevention of Viral Infections Post Hematopoietic Stem Cell Transplant    
Michael Keller, MD, Children’s National Health System


NGS Reveals Repertoire Restriction of  Treg Cells in APDS1 Patients    
Ottavia Delmonte, MD, PhD, NIAID


CVID Plasma Promotes Early Commitment to the Follicular Lineage
Caroline Khanna, Children’s Hospital of Philadelphia


Functional Determination of All Possible Disease-associated Variants of a Region in CARD11 Using Saturation Genome Editing    
Richard James, PhD, Seattle Children’s Research Institute

 

12:30pm - 1:30pm

Saturday Poster Session

 

1:30pm - 3:00pm

Plenary Session #10: Biome

1.5 AMA PRA Category 1 Credits TM 

Moderators:

Shanmuganathan Chandrakasan, MD, Emory University School of Medicine, Children's Healthcare of Atlanta
Elizabeth Kang, MD, NIH

 

Speaker:

Relevance of the microbiome in HCT, and differences between malignancies and immunological disorders
Jonathan Peled, MD, PhD, MSKCC

 

Host-Pathogen Interactions at Mucosal Surfaces:  Relevance for Immune Disorders
Julie Segre, PhD, NIH

 

Oral Abstract:

 

Patients with Chronic Granulomatous Disease Have Distinct Intestinal Microbiome and Metabolomic Signatures
Emilia L. Falcone, MD, PhD, IRCM-Montreal Clinical Research Institute

 

3:00pm - 4:00pm

CIS Business Meeting

 

4:00pm - 4:30pm

Afternoon Break

 

4:30pm - 5:30pm

Richard Schiff Lecture

1 AMA PRA Category 1 Credits TM 

Moderator:

Charlotte Cunningham-Rundles, MD, PhD, Mt. Sinai Medical Center

 

Speaker:

Vaccines in Infectious Diseases
Rafi Ahmed, PhD, Emory University

 

5:30pm - 6:30pm

Closing Reception--Complimentary for all Annual Meeting Attendees

 

6:30pm - 8:30pm

CIS Talent Show to Benefit the CIS Foundation


$20 Admission Fee

  Sunday, April 7

7:00am - 8:00am

Breakfast

 

8:00am - 10:30am

Plenary Session #11: Hot New Defects in PIDs

2.5 AMA PRA Category 1 Credits TM 

Moderator:

Monica Lawrence, MD, University of Virginia
Steve Holland, MD, NIH

 

Speakers:

IL-6 Receptor Deficiency
Josh Milner, MD, NIAID, NIH

 

Partners in Crime:A New Class Switch Defect
Lisa Forbes Satter, MD, Baylor College of Medicine

 

The Human and Immunological Basis of Tree Man Syndrome
Vivien Béziat, PhD, Institut Imagine

 

A Monogenic but Common Basis of Tuberculosis
Stephanie Boisson-Dupuis, PhD, The Rockefeller University

 

Oral Abstracts:

Novel Primary Immunodeficiency with Lymphoproliferative Disease Due to Biallelic Defects in NCKAP1L
Ivan Chinn, MD, Baylor College of Medicine

 


 

Poster Presenter Information

Congratulations on having your abstract selected as a poster for the 2019 Annual Meeting! Below is information regarding the poster sessions at the 2019 Annual Meeting.

 

POSTER SESSIONS: NEW in 2019

All poster sessions will be held in Atrium B&C at the Marriott Marquis. This year, CIS will be running two separate poster sessions: Friday, April 5th and Saturday, April 6th. Sessions will run from 12:30 to 1:30 each day and each accepted poster has been assigned a specific day for presentation.

 

View Your Assigned Poster Session

 

POSTERS PRESENTED ON FRIDAY

  • Posters may be hung up Thursday, April 4th or before the 12:30pm session on Friday, April 5th
  • Posters must be taken down by 3:30pm on Friday, April 5th

POSTERS PRESENTED ON SATURDAY

  • Posters may be hung up after 3:30pm on Friday, April 5th or prior to the 12:30pm session on Saturday, April 6th
  • Posters must be taken down by 3:30pm on Saturday, April 6th

 

POSTER DIMENSIONS

The usable space on the 4ft x 8ft poster boards is 46” high x 94” wide (Landscape orientation). Please keep your poster to a size that will fit these dimensions. While CIS does not have any specific requirements for what must be included on your poster or formatting requirements, we ask that poster presenters use a format that will make it easy for viewers to view from three to five feet away.

 

If you have any questions or updates regarding your poster, please contact Sarah Tulley at stulley@clinimsoc.org or at 414-224-8095.



LIGHTNING POSTER ADDITIONAL INFORMATION

For those individuals who have been selected to do a lightning poster presentation, please follow the guidelines above when developing your physical poster that will be hung in the CIS poster hall.

 

All lightning poster presenters will have 4 minutes to present and 2 minutes for questions. This time will be strictly enforced by the moderators of your session. For your lightning poster presentation, below are the guidelines that must be followed for your presentations.

 

 

LIGHTNING PRESENTATION SLIDES GUIDELINES:

Please follow the guidelines below when developing your presentation slides. You will have 3 slides to present your information and do not include any complex animations in your slides.

  • Slide #1 – Cover Slide
    • Poster title
    • Authors with poster presenter’s name highlighted in RED
    • Institutional affiliation of the presenting author
  • Slide #2 – Problem and Hypothesis
    • 1 sentence statement of the problem addressed by the poster AND
    • 1 sentence statement of the hypothesis
  • Slide #3 – Data and Conclusions
    • 1-2 Key pieces of data
    • 2 bullets listing the 2 most important findings of the study.

 

**IMPORTANT** All slides must be submitted by Wednesday, March 14th for review. Any slides that do not meet the criteria above will be asked to revise before the meeting.

 

Please send your slide deck to Sarah Tulley, stulley@clinimmsoc.org , by March 14thth.
 


Registration

What is included in your registration fee?

  • Name Badge and Printed Program
  • Access to all educational sessions (excluding those with additional registration costs)
  • The following meals will be provided to all attendees, along with breaks throughout the conference:
    • Friday & Saturday: Breakfast and Lunch
    • Saturday: Closing Reception
    • Sunday: Breakfast
  • Access to the Exhibit and Poster Hall throughout the conference
  • Access to the Virtual Meeting after the Annual Meeting concludes
     

Registration Fees

Thymus Symposium

Early Registration
October 1, 2018 - February 1, 2019
Advance Registration
February 2, 2019 - March 8, 2019
Wednesday Thymus Symposium $100 $100

Pre-Conference

Early Registration
October 1, 2018 - February 1, 2019
Advance Registration
February 2, 2019 - March 8, 2019
Pre-Conference Only $250 $300
Pre-Conference w/ Annual Meeting $200 $250

Annual Meeting

Early Registration
October 1, 2018 - February 1, 2019
Advance Registration
February 2, 2019 - March 8, 2019
CIS Regular Member $450 $550
CIS Trainee Member $100 $100
CIS Associate / Allied Health Member $200 $250
Non-Member $650 $750
Non-Member: Trainee $150 $150
Non-Member: Allied Health $300 $400
Industry/Sponsor/Exhibitor $350 $350
Developing Country
(Member or Non-Member)
$200 $250
One Day Registration
(Member or Non-Member)
$250 $300
Dignostic Genomics 101 $15 $15
Functional Validation 102 $15 $15

 

Registration will be available onsite in Atlanta after online registration closes on March 8, 2019. The pricing will remain the same as the Advance Registration.


 

Hotel Information

Marriott Marquis
265 Peachtree Center Avenue
Atlanta, GA 30303 USA

 

The 2019 Annual Meeting will take place at the Marriott Marquis in Atlanta, Georgia. Located in the heart of Downtown Atlanta, the Marriott Marquis is the ideal location from which to explore Atlanta. The Georgia Aquarium, the World of Coca Cola, and Centennial Park are all nearby. Reservation cut-off is March 15, or whenever the CIS room block sells out.

 

CIS has secured a rate of $185/night (not including taxes fees) for anyone who books under the CIS room block.

 

 


 

Exhibitor Information

Exhibit space is now available for purchase at the 2019 CIS Annual Meeting!

 

The 2019 Annual Meeting is the ideal opportunity to meet hundreds of decision making healthcare professionals in specialties related to research, diagnostic and clinical immunology, and educate them about your products and services.

 

Join us for this exciting and intellectually stimulating meeting that promises to be one of the best conferences on primary immunodeficiencies and immune dysregulatory diseases. Applications can be found in the Exhibitor Prospectus.


Costs:

10’x10’ Booth:  $2,500.00

Additional 10’x10’ Booth:  $1,250.00

Non-Profit Rate: $1,250 per 10’x10’


Deadline:

Exhibitor Applications must be received by
February 22, 2019.

Important Dates

 

March 8

Online Registration Closes (Onsite registration available)

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