Summary:Capromab pendetide (ProstaScint) is a murine monoclonal IgG1k directed against prostate specific membrane antigen (PSMA) for use as a diagnostic imaging modality. PSMA expression is higher in prostate adenocarcinoma cells than in nonmalignant cells, and it is higher in metastatic lesions than in primary lesions. Capromab pendetide is indicated as an adjunctive imaging tool in newly diagnosed patients suspected to be high-risk for pelvic lymph node metastases, and in post prostatectomy patients with a rising PSA and a negative or equivocal standard metastatic evaluation, in whom there is a high clinical suspicion of occult metastatic disease. Other monoclonal antibodies, directed at extracellular PSMA binding sites, are also under development.

 Capromab is conjugated with Indium-111 within 8 hours of use. Indium-111 is a radioactive isotope (g emission) with a half-life of 2.8 days. Imaging by SPECT will demonstrate sites of metastatic prostatic cancer, although false positives and false negatives are sufficiently frequent that the scans need to be interpreted carefully in light of additional clinical data.

 Adverse reactions include changes in blood pressure and abnormalities of the liver function tests. A minority of patients produces antibodies to capromab (human anti-mouse antibodies, or HAMA), of uncertain clinical significance.
Allergic reactions, including anaphylaxis, can occur in patients.
ReferencesPrescribing information: http://www.prostascintimaging.com/assets/pdf/ProstaScintPI.pdf
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