Interferon beta-1a

Compound Name:Interferon beta-1aMolecular Target:Type I interferon receptorsMolecular Structure:recombinant human physiologic protien, glycosylatedLicensed Indication:relapsing forms of multiple sclerosisManufacturer and/or Distributor:Biogen IdecInitial FDA Approval:1996Summary:Interferon beta-1a (Avonex) is a recombinant form of a physiologic human type I interferon important for antiviral, immunomodulatory and antiproliferative effects. Binding of interferon beta-1a to its receptor leads to induction of many interferon inducible genes, including beta 2-microglobulin and neopterin, both of which can serve as biomarkers for interferon beta-1a administration. Avonex is produced in Chinese Hamster Ovary cells. The recombinant protein is glycosylated and is identical to the native protein in sequence (MW 22.5kDa). Avonex is administered by weekly intramuscular injections. Avonex was approved by the FDA in 1996 for the treatment of the relapsing form of multiple sclerosis. It has been shown to slow the progression of physical disability and to prevent exacerbations and the accumulation of MRI lesions. The mechanism of action of the therapeutic effects remains unclear. In 2014, the FDA approved a new form of this medication Plegridy (“pegylated” form of interferon) for the approved treatment of relapsing
 MS. Plegridy can be administered subcutaneously every two weeks. The most common side effects reported are flu-like symptoms (chills, fever, myalgia, asthenia), local injection site reaction, and headache. Serious less common safety concerns include hepatic injury, anaphylaxis, congestive heart failure, cytopenias, autoimmune disorders and depression, suicide and psychosis.References

Package Insert: Updated 03/2016


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